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And here I must observe also that the plague, as I suppose all distempers do, operated in a different manner on differing constitutions; some were immediately overwhelmed with it, and it came to violent fevers, vomitings, insufferable headaches, pains in the back, and so up to ravings and ragings with those pains; others with swellings and tumours in the neck or groin, or armpits, which till they could be broke put them into insufferable agonies and torment; while others, as I have observed, were silently infected, the fever preying upon their spirits insensibly, and they seeing little of it till they fell into swooning, and faintings, and death without pain. I am not physician enough to enter into the particular reasons and manner of these differing effects of one and the same distemper, and of its differing operation in several bodies; nor is it my business here to record the observations which I really made, because the doctors themselves have done that part much more effectually than I can do, and because my opinion may in some things differ from theirs. I am only relating what I know, or have heard, or believe of the particular cases, and what fell within the compass of my view, and the different nature of the infection as it appeared in the particular cases which I have related; but this may be added too: that though the former sort of those cases, namely, those openly visited, were the worst for themselves as to pain—I mean those that had such fevers, vomitings, headaches, pains, and swellings, because they died in such a dreadful manner—yet the latter had the worst state of the disease; for in the former they frequently recovered, especially if the swellings broke; but the latter was inevitable death; no cure, no help, could be possible, nothing could follow but death. And it was worse also to others, because, as above, it secretly and unperceived by others or by themselves, communicated death to those they conversed with, the penetrating poison insinuating itself into their blood in a manner which it is impossible to describe, or indeed conceive.

This infecting and being infected without so much as its being known to either person is evident from two sorts of cases which frequently happened at that time; and there is hardly anybody living who was in London during the infection but must have known several of the cases of both sorts.

(1) Fathers and mothers have gone about as if they had been well, and have believed themselves to be so, till they have insensibly infected and been the destruction of their whole families, which they would have been far from doing if they had the least apprehensions of their being unsound and dangerous themselves. A family, whose story I have heard, was thus infected by the father; and the distemper began to appear upon some of them even before he found it upon himself. But searching more narrowly, it appeared he had been affected some time; and as soon as he found that his family had been poisoned by himself he went distracted, and would have laid violent hands upon himself, but was kept from that by those who looked to him, and in a few days died.

(2) The other particular is, that many people having been well to the best of their own judgement, or by the best observation which they could make of themselves for several days, and only finding a decay of appetite, or a light sickness upon their stomachs; nay, some whose appetite has been strong, and even craving, and only a light pain in their heads, have sent for physicians to know what ailed them, and have been found, to their great surprise, at the brink of death: the tokens upon them, or the plague grown up to an incurable height.

It was very sad to reflect how such a person as this last mentioned above had been a walking destroyer perhaps for a week or a fortnight before that; how he had ruined those that he would have hazarded his life to save, and had been breathing death upon them, even perhaps in his tender kissing and embracings of his own children. Yet thus certainly it was, and often has been, and I could give many particular cases where it has been so. If then the blow is thus insensibly striking—if the arrow flies thus unseen, and cannot be discovered—to what purpose are all the schemes for shutting up or removing the sick people? Those schemes cannot take place but upon those that appear to be sick, or to be infected; whereas there are among them at the same time thousands of people who seem to be well, but are all that while carrying death with them into all companies which they come into.

This frequently puzzled our physicians, and especially the apothecaries and surgeons, who knew not how to discover the sick from the sound; they all allowed that it was really so, that many people had the plague in their very blood, and preying upon their spirits, and were in themselves but walking putrefied carcases whose breath was infectious and their sweat poison, and yet were as well to look on as other people, and even knew it not themselves; I say, they all allowed that it was really true in fact, but they knew not how to propose a discovery.

My friend Dr Heath was of opinion that it might be known by the smell of their breath; but then, as he said, who durst smell to that breath for his information? since, to know it, he must draw the stench of the plague up into his own brain, in order to distinguish the smell! I have heard it was the opinion of others that it might be distinguished by the party's breathing upon a piece of glass, where, the breath condensing, there might living creatures be seen by a microscope, of strange, monstrous, and frightful shapes, such as dragons, snakes, serpents, and devils, horrible to behold. But this I very much question the truth of, and we had no microscopes at that time, as I remember, to make the experiment with.

It was the opinion also of another learned man, that the breath of such a person would poison and instantly kill a bird; not only a small bird, but even a cock or hen, and that, if it did not immediately kill the latter, it would cause them to be roupy, as they call it; particularly that if they had laid any eggs at any time, they would be all rotten. But those are opinions which I never found supported by any experiments, or heard of others that had seen it; so I leave them as I find them; only with this remark, namely, that I think the probabilities are very strong for them.

Some have proposed that such persons should breathe hard upon warm water, and that they would leave an unusual scum upon it, or upon several other things, especially such as are of a glutinous substance and are apt to receive a scum and support it.

But from the whole I found that the nature of this contagion was such that it was impossible to discover it at all, or to prevent its spreading from one to another by any human skill.

Here was indeed one difficulty which I could never thoroughly get over to this time, and which there is but one way of answering that I know of, and it is this, viz., the first person that died of the plague was on December 20, or thereabouts, 1664, and in or about long Acre; whence the first person had the infection was generally said to be from a parcel of silks imported from Holland, and first opened in that house.