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The most important of the affections which concern the whole body remains to be considered—that is, the cause of pleasure and pain in the perceptions of which I have been speaking, and in all other things which are perceived by sense through the parts of the body, and have both pains and pleasures attendant on them. Let us imagine the causes of every affection, whether of sense or not, to be of the following nature, remembering that we have already distinguished between the nature which is easy and which is hard to move; for this is the direction in which we must hunt the prey which we mean to take. A body which is of a nature to be easily moved, on receiving an impression however slight, spreads abroad the motion in a circle, the parts communicating with each other, until at last, reaching the principle of mind, they announce the quality of the agent. But a body of the opposite kind, being immobile, and not extending to the surrounding region, merely receives the impression, and does not stir any of the neighbouring parts; and since the parts do not distribute the original impression to other parts, it has no effect of motion on the whole animal, and therefore produces no effect on the patient. This is true of the bones and hair and other more earthy parts of the human body; whereas what was said above relates mainly to sight and hearing, because they have in them the greatest amount of fire and air. Now we must conceive of pleasure and pain in this way. An impression produced in us contrary to nature and violent, if sudden, is painful; and, again, the sudden return to nature is pleasant; but a gentle and gradual return is imperceptible and vice versa. On the other hand the impression of sense which is most easily produced is most readily felt, but is not accompanied by pleasure or pain; such, for example, are the affections of the sight, which, as we said above, is a body naturally uniting with our body in the day-time; for cuttings and burnings and other affections which happen to the sight do not give pain, nor is there pleasure when the sight returns to its natural state; but the sensations are clearest and strongest according to the manner in which the eye is affected by the object, and itself strikes and touches it; there is no violence either in the contraction or dilation of the eye. But bodies formed of larger particles yield to the agent only with a struggle; and then they impart their motions to the whole and cause pleasure and pain—pain when alienated from their natural conditions, and pleasure when restored to them. Things which experience gradual withdrawings and emptyings of their nature, and great and sudden replenishments, fail to perceive the emptying, but are sensible of the replenishment; and so they occasion no pain, but the greatest pleasure, to the mortal part of the soul, as is manifest in the case of perfumes. But things which are changed all of a sudden, and only gradually and with difficulty return to their own nature, have effects in every way opposite to the former, as is evident in the case of burnings and cuttings of the body.

Thus have we discussed the general affections of the whole body, and the names of the agents which produce them. And now I will endeavour to speak of the affections of particular parts, and the causes and agents of them, as far as I am able. In the first place let us set forth what was omitted when we were speaking of juices, concerning the affections peculiar to the tongue. These too, like most of the other affections, appear to be caused by certain contractions and dilations, but they have besides more of roughness and smoothness than is found in other affections; for whenever earthy particles enter into the small veins which are the testing instruments of the tongue, reaching to the heart, and fall upon the moist, delicate portions of flesh—when, as they are dissolved, they contract and dry up the little veins, they are astringent if they are rougher, but if not so rough, then only harsh. Those of them which are of an abstergent nature, and purge the whole surface of the tongue, if they do it in excess, and so encroach as to consume some part of the flesh itself, like potash and soda, are all termed bitter. But the particles which are deficient in the alkaline quality, and which cleanse only moderately, are called salt, and having no bitterness or roughness, are regarded as rather agreeable than otherwise. Bodies which share in and are made smooth by the heat of the mouth, and which are inflamed, and again in turn inflame that which heats them, and which are so light that they are carried upwards to the sensations of the head, and cut all that comes in their way, by reason of these qualities in them, are all termed pungent. But when these same particles, refined by putrefaction, enter into the narrow veins, and are duly proportioned to the particles of earth and air which are there, they set them whirling about one another, and while they are in a whirl cause them to dash against and enter into one another, and so form hollows surrounding the particles that enter—which watery vessels of air (for a film of moisture, sometimes earthy, sometimes pure, is spread around the air) are hollow spheres of water; and those of them which are pure, are transparent, and are called bubbles, while those composed of the earthy liquid, which is in a state of general agitation and effervescence, are said to boil or ferment—of all these affections the cause is termed acid. And there is the opposite affection arising from an opposite cause, when the mass of entering particles, immersed in the moisture of the mouth, is congenial to the tongue, and smooths and oils over the roughness, and relaxes the parts which are unnaturally contracted, and contracts the parts which are relaxed, and disposes them all according to their nature;—that sort of remedy of violent affections is pleasant and agreeable to every man, and has the name sweet. But enough of this.

The faculty of smell does not admit of differences of kind; for all smells are of a half-formed nature, and no element is so proportioned as to have any smell. The veins about the nose are too narrow to admit earth and water, and too wide to detain fire and air; and for this reason no one ever perceives the smell of any of them; but smells always proceed from bodies that are damp, or putrefying, or liquefying, or evaporating, and are perceptible only in the intermediate state, when water is changing into air and air into water; and all of them are either vapour or mist. That which is passing out of air into water is mist, and that which is passing from water into air is vapour; and hence all smells are thinner than water and thicker than air. The proof of this is, that when there is any obstruction to the respiration, and a man draws in his breath by force, then no smell filters through, but the air without the smell alone penetrates. Wherefore the varieties of smell have no name, and they have not many, or definite and simple kinds; but they are distinguished only as painful and pleasant, the one sort irritating and disturbing the whole cavity which is situated between the head and the navel, the other having a soothing influence, and restoring this same region to an agreeable and natural condition.